AMA Arch Surg. 1954;68(3):397-402. doi:10.1001/archsurg.1954.01260050399020.
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THE STUDY of cancer including its diagnosis and treatment appears to be reaching its most intensive phase currently. Familial and hereditary predispositions, environmental influences of many kinds, racial tendencies, and other factors are all under profound scrutiny now in the battle against cancer. Of great interest and possibly of more than mere statistical value are the cases of multiple malignant lesions occurring in the same person. It is well known to the oncologist that, in general, those patients having developed one malignant lesion will have an increased tendency to subsequent affliction by additional primary cancers.6 However, a breakdown of these large series of cases presenting multiple tumors, as has recently been reported by Mider and his associates,1 reveals that this so-called increased cancer susceptibility is probably limited to only a few sites, for example, colon and female breast. Even in the groups of colon and breast cancer patients,


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