AMA Arch Surg. 1954;68(6):800-819. doi:10.1001/archsurg.1954.01260050802010.
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DURING the past two years we have had occasion to administer corticotropin (ACTH) as an adjunct to the surgical treatment of certain selected patients with thyrotoxicosis. This paper is a record of our experiences and an account of some practical and theoretical justifications for this plan of management.

Since corticotropin and cortisone have become generally available, an enormous amount of work has been done with a view to determining their influence on various disease processes. Surprisingly, in spite of the long known interrelationship between the adrenal and thyroid glands, very little has been written concerning the effect of corticotropin and cortisone on thyroid disease. This is not because surgeons are unaware of the value of these hormones. With their aid, as Hume and Moore have said, it is possible to raise to eucorticism a peripheral supply of steroids low because of endocrine disease or the increased need of tissues under


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