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Functioning metastases from Islet-Cell Tumor of the Pancreas:  Control with Corticotropin (ACTH)

CONRAD J. BAUMGARTNER, M.D.; JOHN L. REYNOLDS, M.D.
AMA Arch Surg. 1955;70(6):793-800. doi:10.1001/archsurg.1955.01270120001001.
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In 1927, Dr. William J. Mayo1 discovered the first functioning metatastic islet-cell carcinoma, and one year later Roscoe Graham2 removed the first benign functioning adenoma. Since that time between 400 and 500 case reports of islet-cell tumors have appeared in the literature. By 1950, Howard, Moss, and Quarrie3 had collected 398 cases, and, by 1952, Whipple4 reported a personal collection of 34 patients. For the average surgeon, however, this entity will remain a rarity, particularly the malignant tumor, as only about 10% of islet-cell tumors are frankly malignant and about half of these will have functioning metatastases.

The control of the hypoglycemia in such situations not amenable to surgery presents a challenge to the surgeon. We wish herewith to report our experience with one such patient.

REPORT OF A CASE  Mrs. E. L., aged 59, was first seen by one of us (C. J. B.) in

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