Vagotomy, while interrupting the reflex stimulation of the parietal cells of the stomach, does not prevent the direct stimulation of these cells by histamine or allied substances, although after vagotomy the secretory response to histamine is quantitatively lowered.* Theoretically, therefore, vagotomy cannot be expected to protect the experimental animal from peptic ulceration induced by histamine. However, the secondary effects of vagotomy in lowering gastric tone and prolonging gastric retention might be expected to alter the site of the ulceration so produced.
A method of producing a long-acting histamine preparation by suspending the drug in yellow wax U.S.P. and liquid petrolatum was first described by Code and Varco3 in 1940. The effect of the daily injection of this product on various animals and experimental surgical preparations was reported subsequently by these workers4 and others. Wangensteen and others5 reported the effect of injecting vagotomized dogs daily with 30 mg.