There has long been an interest in the role played by the duodenum in gastrointestinal physiology. Numerous reports have appeared describing the secretions of the duodenum and the regulatory role played by the duodenum in the control of secretions from the stomach, gall bladder, and pancreas. However, much that is known about duodenal physiology has been learned indirectly by intubation of patients or animals and by the study of isolated short segments of duodenum. These methods, while they have been productive of much valuable information, have severe limitations. Though Walters and Bollman1 succeeded in completely isolating the duodenum, they made no attempt to study the secretion quantitatively.
In this laboratory methods have been developed for the quantitative collection of gastric juice from dogs. With modern operative techniques, as well as a better understanding of fluid and electrolyte balance, it has been possible to prepare many types of gastric pouch