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A Comparison of Some newer Anticoagulants

AMA Arch Surg. 1956;72(1):153-159. doi:10.1001/archsurg.1956.01270190155017.
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For the past two years the hematology service of the Royal Victoria Hospital has been using several different anticoagulants in an attempt to determine which, if any, is the best for routine use and which are most suitable under special conditions. It is the purpose of this paper to describe our experience with the anticoagulants cyclocumarol, 3-( 1′-phenylpropyl)-oxycoumarin (Marcumar), and warfarin sodium * and to compare the action of these drugs with each other and with bishydroxycoumarin (Dicoumarol). Experience with cyclocumarol at the Royal Victoria Hospital has been reported elsewhere.†

METHODS  The selection of cases and the application of anticoagulant therapy have been discussed in detail in previous papers.† In brief, the patients utilized for these studies were those referred to the hematology service for anticoagulant therapy, and no special selection was made. The majority of patients suffered from myocardial infarction or venous thrombosis.In most cases the anticoagulant therapy


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