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Thrombin-Fibrinogen Coagulum as a Nonsuture Method of Nerve Anastomosis

AMA Arch Surg. 1956;73(1):38-46. doi:10.1001/archsurg.1956.01280010040006.
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Certain unsatisfactory features associated with the use of sutures in the conventional methods of apposing nerve ends have stimulated efforts to find better techniques for nerve anastomoses. Young and Medawar1 introduced a nonsuture method of peripheral nerve anastomosis using fortified cockerel plasma with chick embryo extract as a "glue" between the nerve ends in rabbits. This technique was also used by Seddon and Medawar2 with a human median nerve. Tarlov and Benjamin3 repeated these experiments and found considerable reaction and fibrosis with the use of cockerel plasma and chick embryo extract. As a result, they evolved a more satisfactory method of plasma-clot suture using autologous plasma with autologous muscle extract. Subsequently, a rather elaborate technique was developed * using plastic molds of various sizes to contain temporarily the plasma clot in its formative stage.

Because of the tendency for nerve ends united by the plasma clot to separate


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