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Article |

Experimental Chronic Pancreatitis

AMA Arch Surg. 1956;73(4):701-709. doi:10.1001/archsurg.1956.01280040157019.
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Claude Bernard just 100 years ago began the scientific study of pancreatitis by injecting bile and olive oil into the duct.* Since then many able investigators have attacked the problem with a variety of methods and ideas, producing acute pancreatitis without difficulty. Since this paper deals primarily with the chronic phase of the disease, no attempt will be made to review the work on acute pancreatitis. Good discussions may be found in the publications of Opie, 19012; Archibald, 1919 †; Gage and Floyd, 19475; Doubilet and Mulholland, 19486; Floyd and Van Meter, 19517; and, more recently, Sensenig and Bowers8 and Whitrock, Hine, Crane, and McCorkle.9

Chronic pancreatitis, perhaps an even more baffling clinical problem, has not been consistently produced in experimental animals. In a careful review of the literature we were not able to find work directed toward a satisfactory method for creating chronic pancreatitis.


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