Treatment of Inoperable Cancer by Intra-Arterial Administration of Mechlorethamine

AMA Arch Surg. 1957;74(4):516-524. doi:10.1001/archsurg.1957.01280100034005.
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This report describes results obtained from the fractionated, regional intra-arterial administration of mechlorethamine hydrochloride (methyl-bis[β-chlorethyl]amine hydrochloride; HN2) in a series of 60 patients with inoperable cancer. In each instance, oxytetracycline (Terramycin) was given concomitantly with the mechlorethamine. The effects of oxytetracycline were investigated in view of the observations of Barberio, who noted that the simultaneous administration of chlortetracycline (Aureomycin) and mechlorethamine seemed to have a greater adverse influence upon the cancer than mechlorethamine alone.

Methods and Procedure  The femoral artery is cannulated under direct vision, an incision being made inferior to Poupart's ligament, parallel to the course of the artery. After the artery has been mobilized, a small polyethylene catheter is inserted through it into the aorta. If the treatment is for cancer of the pelvis, the polyethylene tube is inserted a few inches above the bifurcation of the aorta. If efforts are being made to alleviate hepatic or


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