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The Influence of the Burn State on the Turnover of Serum Proteins in Human Subjects

TRUMAN G. BLOCKER Jr., M.D.; WILLIAM C. LEVIN, M.D.; JOHN E. PERRY, B.S.; STEPHEN R. LEWIS, M.D.; VIRGINIA BLOCKER, M.D.
AMA Arch Surg. 1957;74(5):792-799. doi:10.1001/archsurg.1957.01280110134018.
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Despite the large amount of data accumulated by balance studies and by similar methods of studying the pattern of response to burns and other trauma, the basic physicochemical disturbances involved require considerable clarification, particularly the relationship of the catabolic and anabolic processes of protein metabolism. In 1952 Pollack and Halpern, in the manual on "Therapeutic Nutrition"17 sponsored by the National Research Council, set forth arguments against the theory of blockage of protein synthesis during the so-called "catabolic phase" following injury and infection, but stressed the fact that "the critical experiment designed to show whether or not any anabolism occurs" during the period "remains to be reported," adding that "the administration of an isotopically labeled amino acid during this phase and its subsequent incorporation into body proteins would prove that anabolism was taking place." Since that time the "critical experiment" has been performed many times, and it is hoped that

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