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Experiences with the Extirpated Canine Lung as a Biologic Oxygenator

GEORGE I. THOMAS, M.D.; JOHN E. JESSEPH, M.D.; NILES C. CHAPMAN, M.D.; K. ALVIN MERENDINO, M.D.
AMA Arch Surg. 1957;75(1):61-68. doi:10.1001/archsurg.1957.01280130065012.
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One of the more interesting oxygenators which has resulted from investigative search in the realm of pump oxygenators is the extirpated dog lung. These lungs, being inexpensive and readily available, have been extensively tested in the laboratory and provide an effective means of oxygenating blood.2,4,5,7,10,11 In these experiments, the blood perfused through the "biologic" oxygenator has been homologous with it, and species difference was not considered. With homologous perfused lungs and, in some instances, perfused autogenous lobes, no deleterious effects on the organ were noticed, even after two hours of perfusion. The features of this extirpated organ adapting it to perform its exchange of oxygen and carbon dioxide have been summarized by Mustard, Chute, and Simmons, who state that it carries out good gaseous exchange without undue trauma to blood constituents, is an excellent filter for bacteria and small clots, and may perform certain detoxification functions.8

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