Infusion Treatment of Shock:  Alkali and Acid in Shock Treatment

AMA Arch Surg. 1957;75(2):210-223. doi:10.1001/archsurg.1957.01280140048009.
Text Size: A A A
Published online

The existing situation in the fluid therapy of shock has been accurately summarized by Wiggers.1

It is generally suspected that the beneficial effects of sodium chloride do not depend solely or largely on its ability to restore plasma volume. It must be due to the action of the sodium or chloride ions or of the NaCl molecule.

Illustrative of the first sentence is the superiority of saline over plasma2-5 or dextran solution.6 The problem of the second sentence is explored in the present paper.

Methods  Tourniquet shock, which was first standardized in rats,2 was produced in dogs by tight constriction of both hindlegs as high as possible with heavy rubber bands or 6 mm. tubing. Anesthesia was induced with pentobarbital (Nembutal) intravenously or intraperitoneally. The animals were awake toward the end of the ligation period, when the limbs had lost sensation. Such constriction for five hours


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.