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Effect of Permanent Alteration of Hepatic Blood Flow upon Biliary Secretion

BERNARD FISHER, M.D.; SIL H. LEE, M.D.; E. J. FEDOR, Ph.D.
AMA Arch Surg. 1958;76(1):41-45. doi:10.1001/archsurg.1958.01280190043008.
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It has been reported previously from this laboratory that following arterialization of the liver approximately 10% of the animals died of acute cholecystitis, and at autopsy common ducts were found distended with biliary "sludge."1 This suggested that perhaps the marked increase in hepatic blood flow attendant on this procedure had altered the character of the bile. Investigation of the literature concerning the relationship of the hepatic blood flow to volume and composition of bile revealed conflicting and incomplete information obtained under conditions not entirely satisfactory.

Recently Popper and associates2 reported that four dogs with complete external bile duct fistulas showed practically no change in secretion following excision of the hepatic artery, or obstruction of the portal vein, or a combination of the two, and they concluded that the blood of the hepatic artery and/or portal vein is not necessary for bile formation. Because of the variability of results

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