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Ivan W. Brown Jr., M.D.; W. Glenn Young, M.D.
AMA Arch Surg. 1958;76(3):475. doi:10.1001/archsurg.1958.01280210145031.
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To the Editor:  —In the August, 1957, issue of this journal there appeared an article by Button, Bernhard, and Walter entitled "In Vitro Oxygenation of Fresh Whole Blood for Arterial Perfusion."These authors describe a simple closed method utilizing ion-exchange resin columns and plastic bags for the collection and in vitro oxygenation of fresh whole blood for arterial perfusion. They propose this as a simple system for arterial perfusion of the circulation during repair of congenital defects of the right heart in children weighing up to 15 kg. and for perfusing the coronary and cerebral afferent vessels as an adjunct in cardiac surgery under hypothermia. The authors cite no results using this system as proposed in either experimental or clinical cardiac operations.When the donor's blood passes through the ion-exchange resin column, it is rendered incoagulable through removal of its divalent cations, the most important of which is calcium. According


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