January 1959, Vol 78, No. 1 >

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ARTICLE | January 1959

Reversal by Ipsilon of Lytic System in Blood Stream Produced in Rabbits by Streptokinase

JOSEPH M. MILLER, M.D.; DANIEL R. ROBINSON, M.D.; DEBORAH A. JACKSON, B.S.; CHARLES S. COLLIER

AMA Arch Surg. 1959;78(1):33-36. doi:10.1001/archsurg.1959.04320010037006.

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Ipsilon (ε-amino-caproic acid) has been reported to have the ability to inhibit completely at a small concentration the activity of plasmin.³ The measurement of antiplasmin power in that investigation was studied by using fibrin clots.

The capacity of Ipsilon to inhibit a lytic system in the blood stream may have considerable promise in clinical medicine. The drug may provide a means of producing coagulation of the blood in patients whose clots undergo spontaneous lysis. Ipsilon might also serve as an antidote in patients who have had a lytic system established by streptokinase for the treatment of thrombosis. A conceivable extension of the use of streptokinase would be to produce an incoagulable blood in patients undergoing cardiac surgery when the heart-lung machine is used with the lytic system reversed by Ipsilon. The many clinical uses to which the drug could be put, particularly to inhibit the effects produced by streptokinase

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MILLER JM, ROBINSON DR, JACKSON DA, COLLIER CS. Reversal by Ipsilon of Lytic System in Blood Stream Produced in Rabbits by Streptokinase. AMA Arch Surg. 1959;78(1):33-36. doi:10.1001/archsurg.1959.04320010037006.

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Reversal by Ipsilon of Lytic System in Blood Stream Produced in Rabbits by Streptokinase

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