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June 1959, Vol 78, No. 6 >
ARTICLE | June 1959

Clinical Use of Intravenous Fat in Surgical Patients

WILLIAM H. MARSHALL, M.D.
AMA Arch Surg. 1959;78(6):851-855. doi:10.1001/archsurg.1959.04320060039005.
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An intravenous fat emulsion (Lipomul I. V.) has recently become available for clinical use. Utilizing a 15% emulsion of cottonseed oil with soybean phosphatides and Pleuronic F-68 ( oxyethyleneoxypropylene polymer) as stabilizers, it is prepared with 4% dextrose in water as a vehicle.1 A preliminary report from the surgical service of the Illinois Research and Educational Hospitals2 indicated that this improved fat emulsion was sufficiently free of side-effects to make it safe for routine clinical use. The most prominent reactions noted in this study were a transient minor hypertensive response in 48% of infusions and a transient temperature elevation in 1.6% of patients.

Studies on this preparation have since been extended to include an additional 95 patients, who have received a total of 580 units of intravenous fat for an average consumption of 6 units per patient. Each unit contained 500 or 600 cc. of fat emulsion, depending on

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