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ARTICLE | September 1959

Experimental Treatment of Tumors with Antibodies

PETER BUINAUSKAS, M.D.; JOHN A. McCREDIE, M.D.; E. R. BROWN, M.D.; WARREN H. COLE, M.D.

AMA Arch Surg. 1959;79(3):432-439. doi:10.1001/archsurg.1959.04320090080012.

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Recently there has been increasing interest in the immunological treatment of cancer. The ultimate aim of the immunologist is to produce an active immunity against cancer. However, the more limited goal of treatment using the principle of passive immunity is now being extensively investigated. Recent work by other workers has shown that it is possible to produce anticancer antibodies in another species of animal, and these antibodies are active when injected back into the animal from which the tumor was derived. The antibodies have been labeled with radioactive iodine and with fluorescein and have been shown to react with the tumor tissue both in vivo and in vitro. These anticancer antibodies appear to be present mainly in the γ-globulin fraction of the plasma.

In 1954, Nungester and Fisher 1 prepared an anticancer serum which was effective in decreasing the number of tumor "takes." They gave six injections of a filtrate

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BUINAUSKAS P, McCREDIE JA, BROWN ER, COLE WH. Experimental Treatment of Tumors with Antibodies. AMA Arch Surg. 1959;79(3):432-439. doi:10.1001/archsurg.1959.04320090080012.

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