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Strangulated Intestinal Obstruction Pathophysiology and Management

AMA Arch Surg. 1959;79(6):864-874. doi:10.1001/archsurg.1959.04320120006002.
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Is the Peritoneal Fluid of Late Strangulation Obstruction Toxic?

Conclusion:  The peritoneal fluid plays a major role in the lethal issue of strangulation obstruction.

What Component of the Fluid Is Responsible for Its Toxic Properties? 

Conclusion:  Bacterial cells appear to be responsible for the toxic properties of strangulation fluid.

After Peritoneal Exposure to Toxic Fluid Do Bacterial Cells Gain Access to the Blood Stream? 

Conclusion:  Bacterial cells may be cultured from the portal or systemic blood after peritoneal exposure to fluid.

Will Antibiotics Prevent the Formation of Toxic Fluid? 

Conclusion:  Antibiotics prevent the formation of toxic strangulation fluid.

Is It Possible to Immunize an Animal Against an Otherwise Lethal Dose of Strangulation Fluid? 

Conclusion:  Previous injections of toxic animal and human strangulation fluid gave significant protection. Fluid arising from a neomycin-treated segment of bowel was not effective.

What Is the Effect of Toxic Strangulation Fluid upon Circulating White Blood Cells? 


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