We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

An Oxygenator for Isolation-Perfusion in the Treatment of Cancer

AMA Arch Surg. 1960;80(3):506-507. doi:10.1001/archsurg.1960.01290200150027.
Text Size: A A A
Published online


Recent introduction of techniques for isolating a region of the body and temporarily perfusing the localized area with oxygenated blood containing a chemotherapeutic agent3-5 has given impetus to the treatment of extremity malignancies. While the disposable bubble oxygenator commercially available for this purpose * is apparently adequate, our laboratory experiments with this apparatus have been complicated by excessive depositions of fibrin within the oxygenator and by oxygen bubble emboli in the arterial flow.

Our previous favorable experience with the rotating disc oxygenator led us to evaluate the efficiency of this machine when used in localized perfusions. Early in our laboratory trials with the technique it became obvious that high flows were neither necessary nor desirable. With the normal circulation intact, the major portion of the cardiac output goes to essential organs, and small blood flows suffice in the extremities. The body as a whole utilizes proportionately more oxygen than resting


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.