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Local Gastric Hypo- and Hyperthermia and Plasma Pepsinogen Concentration in Gastric Veins of Dogs

W. C. MacKENZIE, M.D.; W. PAWLUK, M.D.; K. KOWALEWSKI, M.Ph., Ph.D., M.D.
AMA Arch Surg. 1960;80(5):733-737. doi:10.1001/archsurg.1960.01290220025004.
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Recent work of Wangensteen et al.1,2 showed that gastric digestion, in experimental animals and in man, is significantly retarded or totally inhibited by local gastric hypothermia. The depressive effect of cold on both the volume and the enzymatic activity of gastric juice has been proposed, by these authors, as the cause of this suppression of digestion. Gastric hypothermia, as an inhibitor of peptic enzyme production, has promising clinical application and has already been used in the treatment of massive hematemesis in man.2 This method may also be used as an experimental tool for the study of gastrointestinal function.3

Our previous work on the endocrine activity of stomachs in animals4,5 demonstrated a significant parallelism between the secretion of gastric pepsin and the concentration of plasma pepsinogen. It was also apparent that the changes in concentration of plasma pepsinogen in the gastric veins of dogs reflect adequately the

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