Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Ischemia, pH, and Renal Damage

EDWARD E. MASON, M.D., Ph.D.; JOHN W. WARD, M.D.; CHRISTA DIERKS, Ph.D.; Ursula Mauch; Vera Polehna; Roderick E. Kellogg
Arch Surg. 1960;81(2):186-192. doi:10.1001/archsurg.1960.01300020014003.
Text Size: A A A
Published online


Despite numerous studies of morphologic and functional changes in acute renal insufficiency, there is still no adequate means of determining kidney damage early while that damage is developing, and there is still no means of determining the relative importance of a variety of suspected causal factors. As a result the clinician is hampered in establishing an early diagnosis and prognosis, and has no way of evaluating therapy. In reviewing the extensive literature on the subject, one is impressed by the complexity of the problem, the large number of variables involved, and the seeming hopelessness of drawing any further conclusions without finding some simpler experimental approach for testing hypotheses. For this reason a series of experiments have been carried out through use of (1) the isolated perfused kidney, (2) a limited number of potential noxious variables, and (3) analyses of perfusate and urine for cellular moieties as indices of kidney damage.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.