Toxicity Studies of 5-Fluorouracil Used as an Adjunct to Surgery

Arch Surg. 1960;81(2):244-250. doi:10.1001/archsurg.1960.01300020072011.
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Chemotherapy as an adjunct to surgery has been evaluated both in the experimental animal and clinically by Cole and his co-workers.3,7,10 The Cancer Chemotherapy National Service Center has sponsored a large-scale clinical evaluation among a group of universities and cancer institutes which are employing a common protocol. The drugs presently under study are mechlorethamine (HN2), triethylenethiophosphoramide (TSPA), and chlorambucil. These alkylating agents produced an increased incidence in toxicity, leukopenia, and complications when they were administered as adjuncts to surgery.5,9

5-Fluorouracil has demonstrated clinical usefulness in a number of neoplastic lesions1,4,8 and consideration should be given to its possible use as an adjunct to surgery. This compound when given on a schedule of 15 mg/kg. daily for five days frequently elicits moderate to marked leukopenia, stomatitis, and diarrhea.1,4,8 In a preliminary pilot study the above dose given daily for three or four days produced a profound


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