Respiratory Depression with Intraperitoneal Neomycin

Arch Surg. 1960;81(5):690-698. doi:10.1001/archsurg.1960.01300050012003.
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Respiratory depression was not noted by the authors in more than 100 previous cases where neomycin had been instilled in the human peritoneal cavity (200 ml. of a 1% solution), but tidal volume measurements were not made in these instances.1 Pridgen2 reported four cases of respiratory arrest in which 0.5 gm. was instilled intraperitoneally in each of two infants and 3 gm. in each of two adults. The infants died. The adults survived after undergoing 3 and 48 hours of respiratory depression, respectively. Poth has noted respiratory arrest in animals and respiratory depression in an infant.3

A fatal adult case is reported in the American Society of Anesthesiologists Newsletter.4 This patient received 2 gm. intraperitoneally with respiratory arrest within 10 minutes. Webber5 reported a case in which 5 gm. was instilled in the peritoneal cavity, producing respiratory arrest with recovery after 15 hours of artificial


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