We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Cardiac Metabolism During Extracorporeal Circulation

Arch Surg. 1961;82(1):138-146. doi:10.1001/archsurg.1961.01300070142017.
Text Size: A A A
Published online


Despite the continued successful employment of the pump-oxygenators in hospitals throughout the world, the metabolic alterations associated with extracorporeal circulation remain a perplexing problem.10,26 The basic mechanisms responsible for these abnormalities have not been completely explained. The changes in vital organ metabolism (heart, brain, kidney, lung and liver) may well prove critical in certain instances, and an understanding of these alterations may be of considerable clinical importance. The etiology of the decreased myocardial function—the so-called cardiac hypotension—following cardiopulmonary bypass which occasionally results in the death of the patient, has been suspected of occurring as a result of metabolic alterations.8 Recent studies of some parameters of myocardial metabolism during cardiopulmonary bypass have been reported.23,36 Additional studies including evaluation of the known cardiac metabolites appear to be indicated, and an investigation of the utilization and production of several metabolites by the myocardium during and after prolonged extracorporeal circulation


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.