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Sulfadimethoxine Use in Chronic Urinary Drainage

Arch Surg. 1961;82(5):719-722. doi:10.1001/archsurg.1961.01300110081011.
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The problem of maintaining prolonged urinary drainage in patients with spinal-cord injuries has for many years taxed the best efforts of urologists and others interested in rehabilitation. Much has been written about the best forms of drainage, use of prophylactic antibacterials, diets, and fluids. Calculus formation, pyelonephritis, and sepsis, in general, all occur at a high incidence rate.1 Sulfonamides have been extensively used in treating and preventing bladder infections since the advent of chemotherapy. Recently, long-acting sulfonamides have come into prominence in efforts to prevent the growth of urinary bacteria. One of these, sulfadimethoxine, which has been widely used for the treatment of upper respiratory infections,2,7 is also useful in the treatment of soft-tissue8 and urologic infections.7,11

Chemically, sulfadimethoxine* is 2,4-dimethoxy-6-sulfanilamido-1,3-diazine with the structural formula seen in the Figure. It is a colorless, odorless, tasteless, crystalline material which melts at 200 to 202 C. The drug


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