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Emylcamate—Its Use in Orthopedic Practice

Arch Surg. 1961;83(2):296-299. doi:10.1001/archsurg.1961.01300140138026.
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The use of emylcamate (Striatran*) in 215 ambulatory patients in orthopedic practice has proved to be a valuable adjunct to our medical armamentarium. A constant search is being conducted for drugs that can aid in the relief of muscle spasm, anxiety, and nervous tension. This report deals with the clinical testing of a new compound—a tertiary alcohol carbamate, Striatran—in the ambulatory treatment of orthopedic patients.

Screening a large series of tertiary alcohols and their esters with the aim of finding the structure of the simplest compound with a full range of tranquilizing and relaxant properties, Melander1 found 1-ethyl-1-methyl propyl carbamate (emylcamate), with the molecular configuration shown in the figure, to be suitable for psychological and clinical evaluation. At an early stage, when the pharmacological studies were conducted in the Research Department of A/B Kabi, special experiments were carried out at the Merck Institute for Therapeutic Research. The outcome of


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