Tumor-Host Relationships in Experimental Incisions

Arch Surg. 1961;83(4):605-610. doi:10.1001/archsurg.1961.01300160117014.
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The occasional recurrence of cancer in surgical incisions and anastomotic sites is well documented.1-3 Investigations have been reported concerning methods of prevention of seeding of cancer cells into wounds during surgery and with local or systemic administration of various chemicals intended to destroy such cells.4 The thesis of this report is that the growth of cancer cells in a wound may be the result of 2 factors: (1) the presence of the cancer cells in the wound, and (2) metabolic interaction between the cancer cells and the wound which allows or stimulates growth of the cancer cells. Such interaction may stimulate or inhibit tumor growth. This thesis is based on observations made in the course of experiments in which transplantable human tumors have been injected into surgical incisions in rats. Two series of experiments are being reported. In the first, the effect of nutrition on tumor growth was


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