Islet-Cell Tumors of the Pancreas

Arch Surg. 1962;85(2):238-244. doi:10.1001/archsurg.1962.01310020068015.
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Introduction  Islet-cell tumors of the pancreas occur relatively infrequently; yet their importance stems from factors involved in their symptomatology, pathological considerations, and dramatic surgical cure in many cases.Nicholls1 in 1902 described the first case of islet-cell adenoma. In 1927, Wilder et al.2 reported a case of islet-cell tumor exhibiting severe hypoglycemic manifestations. Exploration and biopsy performed by W. J. Mayo revealed an islet-cell carcinoma and metastasis to liver and regional lymph nodes. An extract of the liver metastases produced hypoglycemia and shock when injected into rabbits. Roscoe Graham3 in 1929 removed an islet-cell tumor from the body of the pancreas of a patient with the diagnosis made preoperatively, and the patient was known to be living 22 years later even though the lesion was malignant microscopically. Cushing4 successfully effected a surgical cure of a benign adenoma of the pancreas in 1930. Howard et al.5


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