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ARTICLE |

Osteogenic Sarcoma in a Luminous Watch Dial Painter

CARL DAVIS JR., M.D.; R. GORDON BROWN, M.D.; R. W. ALEXANDER, M.D.
Arch Surg. 1963;86(2):190-195. doi:10.1001/archsurg.1963.01310080014004.
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After the isolation and identification of radium by the Curies, radium and other closely related radioactive elements were utilized in the treatment of a number of medical disorders, particularly gout,1 arthritis,2,3 syphilis,4 hypertension,5 epilepsy, multiple sclerosis,6 leukemia,7 and various types of anemia.8-10 The oral and intravenous use of radium was well established not only in this country, but also abroad. Although the toxic manifestations of radium and its associated elements were not well defined at that time, there was, nonetheless, much enthusiasm for this mode of therapy because of the presumed clinical improvement in a large number of cases. Looney et al.11 recently emphasized that toxic effects were not anticipated to develop 10 to 20 years after the use of radium therapy. It has been stated that the administration of soluble radium salts has continued, at intervals, until the present time in

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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