Since the classic theory of Opie5 postulating the reflux of bile into the pancreatic duct by virtue of a common channel, various therapeutic agents have been evaluated in both clinical trials and experimental animals. Recent studies7-10 have demonstrated that death in canine experimental hemorrhagic pancreatitis induced by injection of bile into pancreatic ducts can largely be prevented by use of certain antibiotics. Thus, a prerequisite in the evaluation of beneficial effects of therapeutic agents in lowering the mortality rates in acute canine pancreatitis is the recognition and prevention of the susceptibility of dogs, under adverse conditions, to fulminating infections. Hara and associates3 have described a method of producing a sterile yet highly lethal form of acute hemorrhagic pancreatitis in dogs.
In 1954, Starr,11 in reviewing the modern approach to treatment of pancreatitis, recommended the use of 3-5 gm. of propylthiouracil. No comments were made on its