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ARTICLE |

Chemotherapy of Human Cancer with Sulfhydryl Inhibitors

FRANCES E. KNOCK, M.D.
Arch Surg. 1963;86(3):489-494. doi:10.1001/archsurg.1963.01310090139026.
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The importance of sulfhydryl compounds, to the mitotic apparatus of cells and to multiple metabolic reactions of cells, has encouraged investigation of sulfhydryl inhibitors for surgical and chemical attack on cancer. To guide the chemical syntheses1-6 and to compare activity of sulfhydryl inhibitors with that of other available durgs, in vitro agar plate assays7-9 are used with each patient's cancer cells removed at surgery. Immediately after surgery, drugs are placed in contact with the cancer cells for four hours at 37 C, and a redox indicator is then applied. Results are read by midnight of the day of surgery. This rapidity of testing under physiologic conditions obviates to some extent the difficulties arising from the "feast to famine" type of nutrition inherent in all static tissue-culture methods.10

In 40 of 40 consecutive agar plate assays on varying types of living human cancer cells, the activity of one or

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