Recent work of Altamirano and Chiang1 in our laboratory demonstrated that stimulation of the splanchnic nerve and of the gastric sympathetic nerves produces a rise in pepsinogen secretion from the gastric glands, previous to injection of 0.1 mg. histamine per kilogram body weight.
Heath et al.13,15 reported marked increase in outpouring of urinary 17-ketosteroids, a significant drop in circulating eosinophils, and an increase of 200% to 300% in total white blood cell count with stimulation to the septal region in rhesus monkeys. After adrenalectomy, changes in these measurements of essentially the same magnitude occurred with repetition of the stimulus to the septal region, suggesting that these indicators of the stress response from brain stimulation were not dependent upon the adrenals.
Folkow and von Euler5 demonstrated that hypothalamic stimulation in the cat induced a secretion of epinephrine and arterenol from the adrenal gland in varying proportions, depending on