Enzyme Histochemical Studies on Surgically Resected Breasts

Arch Surg. 1963;86(4):593-599. doi:10.1001/archsurg.1963.01310100077012.
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Introduction  Histochemical observations on the distribution of various substances such as glycogen, protein-bound sulfhydryl groups, mucoprotein, glycoprotein, hyaluronic acid, and polysaccharides have been made in the normal and the diseased breast.5,7,8,13,15 However, observations on the distribution of hydrolytic and oxidative enzymes in this organ have been limited to that of alkaline and acid phosphatase, nonspecific esterase, and succinic dehydrogenase.1,5,7,9,13,14We undertook to study, histochemically, the distribution of a group of enzymes in the surgically resected breast, to observe the normal pattern and its alterations in disease. Furthermore, an attempt was made to correlate these findings with the morphologic pattern observed with hematoxylin and eosin stains and with the clinical findings. Also, the results were briefly compared with those obtained biochemically by other investigators.

Material and Methods  Fifteen surgical specimens (nine cancer, seven fibrocystic disease and three fibroadenoma) were collected immediately after excision. These were either subjected to neutral


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