Cartilage Speeds Healing in Diabetic Wounds

Arch Surg. 1963;87(4):647-649. doi:10.1001/archsurg.1963.01310160109021.
Text Size: A A A
Published online

Prudden and his collaborators have consistently shown an acceleration of wound healing in normal rats by the topical application of digested bovine cartilage powder, or by the subcutaneous implantation of cartilage pellets at a distance from the wound.9 Prior work in our laboratory has shown that the healing of sutured incised wounds is impaired in animals with alloxan diabetes, and that this impairment may be partially or completely corrected by adequate control of the diabetic state.11,12

It seemed appropriate, therefore, to determine whether or not locally applied bovine cartilage powder would correct the healing defect in poorly controlled diabetic animals.

Methods  Male albino Wistar rats weighing from 150 to 200 gm were used. The normal blood sugar values in this strain range from 65 to 120 mg%. Diabetes was induced in animals which had been fasting for 48 hours by intraperitoneal injection of alloxan (150 mg/kg), one hour


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.