Prudden and his collaborators have consistently shown an acceleration of wound healing in normal rats by the topical application of digested bovine cartilage powder, or by the subcutaneous implantation of cartilage pellets at a distance from the wound.9 Prior work in our laboratory has shown that the healing of sutured incised wounds is impaired in animals with alloxan diabetes, and that this impairment may be partially or completely corrected by adequate control of the diabetic state.11,12
It seemed appropriate, therefore, to determine whether or not locally applied bovine cartilage powder would correct the healing defect in poorly controlled diabetic animals.
Male albino Wistar rats weighing from 150 to 200 gm were used. The normal blood sugar values in this strain range from 65 to 120 mg%. Diabetes was induced in animals which had been fasting for 48 hours by intraperitoneal injection of alloxan (150 mg/kg), one hour