0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Mannitol and Renal Function in Cardiovascular Surgery

LEONARD B. BERMAN, MD; LOUIS L. SMITH, MD; GEOFFREY D. CHISHOLM, MD; RAYMOND E. WESTON, MD
Arch Surg. 1964;88(2):239-243. doi:10.1001/archsurg.1964.01310200077017.
Text Size: A A A
Published online

Acute renal insufficiency of various etiologies is presently associated with high mortality rates in spite of modern methods of treatment.1 The possibility of preventing its occurrence rightly commands our attention. The initial reports of Barry and his colleagues2,3 suggested that the osmotic diuretic, mannitol, exerted a protective action on the kidney when given prior to, and during, aortic cross clamping above the renal arteries. A large number of papers followed claiming that the incidence of acute renal insufficiency is reduced when mannitol is given promptly in situations varying from hemorrhagic shock to poisoning with nephrotoxic chemicals. Many of these appear in the proceedings of a symposium held in 1962.4 Others are in the form of isolated case reports.5 Although much of the animal data seems encouraging,4,6 evaluation of the clinical studies has been hampered by the low incidence of acute renal insufficiency and the difficulty

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();