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Effect of Splenectomy on Tolerance to Thio-Tepa

GEORGE A. HIGGINS JR., MD; THOMAS FLYNN, MD; JOHN GILLESPIE, MD
Arch Surg. 1964;88(4):627-632. doi:10.1001/archsurg.1964.01310220117018.
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In any type of medical therapy careful consideration of possible harmful effects of the therapeutic agent being used is essential—primum non nocere has long been one of the basic precepts of medical practice. One of the primary concerns in establishing the various surgical cancer chemotherapy cooperative groups was the hazard of administering cancer chemotherapy drugs to patients potentially cured of cancer by the operative procedure. One of the factors leading to the choice of mechlorethamine hydrochloride (nitrogen mustard) and thio-tepa (triethyelene thiophosphoramide) as the anticancer agents to be used in the Veterans Administration Adjuvant Cancer Chemotherapy Study was the considerable clinical experience which had accumulated in the usage and toxic manifestation of these drugs.8 The dosage regimen selected to be administered to patients undergoing excisional surgery was essentially the same as that used in numerous patients being treated for far advanced visceral cancer or for lymphoma. For

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