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June 1964, Vol 88, No. 6 >
ARTICLE | June 1964

Regional Arterial Infusion for Localized Malignancies

DONALD M. HAYES, MD; F. B. WILKINS, MD; JESSE H. MEREDITH, MD
Arch Surg. 1964;88(6):1070-1076. doi:10.1001/archsurg.1964.01310240166028.
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Malignant tumors of the head and neck region are regarded lightly by many clinicians and have not received the attention given in recent years to malignancies of other portions of the body. Survival rates for patients with such tumors belie this impression and show that these lesions are equally as deadly as other tumors. The five-year survival rate for carcinoma of the tongue has been given as 38.5%, for the buccal mucosa 47.1%, and for the gingiva as 42.2% in one series.1 These tumors are also regarded as less deadly than others because they do not commonly metastasize. However, the study of Rubenfeld et al showed that 28 (21%) of 132 patients with carcinomas of the head and neck region had distant metastases.10 It is obvious from these data that this is indeed a formidable group of tumors and one for which the standard treatment leaves much to

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