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ARTICLE |

Protection Against Nephrotoxicity of Iothalamic Acid

W. G. RHEA JR., MD; D. A. KILLEN, MD; J. H. FOSTER, MD
Arch Surg. 1964;89(2):294-298. doi:10.1001/archsurg.1964.01320020058009.
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Previous studies in this laboratory have quantitated and compared the nephrotoxicity of the various aortographic contrast media.4,8,14 An 80% solution of iothalamic acid (Angio-Conray) has proven to be one of the least nephrotoxic of the currently available aortographic contrast media.1,12,14 However, use of a standardized canine aortic injection technique which permits perfusion of the renal arterial bed by a large volume of undiluted sodium iothalamate produces renal injury sufficient to cause azotemia in the majority of instances.12 Premedication with certain agents (intra-aortic glucose, intra-aortic low molecular weight dextran, and intravenous glucose) has proven effective in decreasing the intensity of the toxic responses to a more toxic aortographic contrast medium, such as sodium acetrizoate (Urokon).2,5-7,9-11,13 The present report describes the results of attempts to minimize or prevent the toxic responses of the kidney to iothalamic acid by the prior administration of these "protective" agents.

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