A REPORT on the structural changes in the canine stomach following gastric freezing has indicated that little human material is available for study.1 During a period of 14 months 90 patients having peptic ulceration of the duodenum or pylorus without significant obstruction were treated with a single gastric freeze for control of symptoms. From this group we have studied tissue from 15 stomachs surgically resected 3 to 537 days after gastric freezing.
Using the technique of Wangensteen and associates,2 gastric freezing was applied for a 60-minute period in all instances using a gastric hypothermia apparatus with a perfusion rate of 500 cc per minute. Inflow temperatures of −15 to −19 C and outflow temperatures of −10 to −14 C were maintained. The volume of the standard, latex rubber balloon was the maximal consistent with patient comfort and is recorded in Table 1. Body temperature was monitored with