... endocrinology and immunology—territories at present separated not so much by an iron curtain as by a wet blanket.
—P. B. Medawar11
IN THE current welter of organ transplantation investigational activity the pancreas has enjoyed a relative immunity. Apparently the complexity and interdependence of pancreatic and duodenal vasculature has served as a temporary transplantation barrier.
Early physiologists succeeded in transplanting the gland to clarify the source and action of insulin.5,6 Some modern workers described their technique of gland transplantation but failed to record function of the graft.3,7 Others, noted function in pancreaticoduodenal grafts, in autografts, and in allografts of the tail of the gland.4,9,14 These studies indicated the possibility of total pancreatic transplantation.
The present work was initiated to assess endocrine function of the total pancreatic allograft and the natural history of such a graft in a canine recipient unmodified except by prior pancreatectomy.
Material and Methods