THE EXISTENCE of a gastric hormone which stimulated acid secretion was first postulated by Edkins1 in 1906. Some 42 years ago Grossman2 clearly demonstrated its existence as liberated by various secretagogues. More recently, elaborate experiments by Oberhelman, et al3 and by Pe Thein and Schofield4 have shown that vagal stimulation can liberate gastrin.* The former suggested that increased peristaltic activity resulting from insulin hypoglycemic vagal stimulation or from the ingestion of food was the basic mechanism for the release of gastrin. But, because of the disassociation of motility and vagal gastrin release noted by Pe Thein and Schofield,4 it has been postulated that there are two types of cholinergic fibers in the gastric antrum; one that mediates gastrin release and one that mediates motility. The following study was designed to study further the intimate mechanism for the vagal release of gastrin.
In each of