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Gastrin and Peptic Ulcer

Arch Surg. 1965;91(6):1005-1010. doi:10.1001/archsurg.1965.01320180139029.
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IN 1955 Zollinger and Ellison1 first called attention to the association of peptic ulcers in the jejunum with islet-cell tumors of the pancreas. This relationship was further elaborated by Ellison2 in 1956. Since this time a considerable number of similar cases have been reported and the characteristic feature of all of them has been a marked hypersecretion of gastric juice, both in empty stomach and in response to food taking. Removal of these tumors was found by Oberhelman and others3 to abolish the hypersecretion and to cause the ulcers to heal. Finally Gregory and associates4 succeeded in extracting a gastrinlike substance from a pancreatic tumor found in association with the ZollingerEllison syndrome, thus completing the chain of evidence establishing the pathogenesis of this type of chronic progressive peptic ulcer. As a result of this newer knowledge a number of lives have been saved, and the physician


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