0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Effects of Isoproterenol and Levarterenol on Blood Flow and Oxygen Use in Hemorrhagic Shock

DALE G. JOHNSON, MD; WILLIAM M. PARKINS, PhD
Arch Surg. 1966;92(2):277-286. doi:10.1001/archsurg.1966.01320200117019.
Text Size: A A A
Published online

THE IMPROVEMENT of vital-organ perfusion is an accepted aim in shock therapy. The most effective approach to this aim is controversial. Adequate blood volume repletion does not necessarily result in an optimal regional distribution of blood flow. The present study was designed to compare the effects of two drugs, levarterenol and isoproterenol, on cardiac output and blood flow to the superior mesenteric and renal vascular beds. Though chemically related, these drugs have divergent effects upon the resistance vessels, levarterenol being a vasoconstrictor and isoproterenol a vasodilator.

Levarterenol was an obvious choice for a vasopressor drug because of its wide clinical usage, its role as an endogenous sympathetic mediator,1 and because of the inconsistency of reported results following its application in experimental and clinical shock. The use of levarterenol to elevate pressure has produced both positive and negative experimental results in terms of survival and measured blood flow data. Reports

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();