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May 1966, Vol 92, No. 5 >
ARTICLE | May 1966

Increased Acid Secretion From Heidenhain Pouches by Shunting Colonic Venous Blood Around the Liver

JAMES S. CLARKE, MD; IRA MILLER, MD; PAUL K. McKISSOCK, MD
Arch Surg. 1966;92(5):653-656. doi:10.1001/archsurg.1966.01320230001001.
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CREATION of a portacaval shunt in the dog is followed by increased secretion of acid from an indicator Heidenhain pouch.1 One explanation for this finding is that a substance is released into the portal blood which has the capacity to stimulate gastric secretion, that it is normally inactivated in the liver, and that its effect becomes prominent when such inactivation is diminished due to diversion of portal blood around the liver. If this explanation is correct, it is of interest to determine where in the portal bed this stimulatory substance originates. We have presented experiments using selective shunting of portal blood which show it originates in the intestine distal to the midportion of the duodenum.2 The present experiments were designed to determine whether it originates in the colon or small bowel or both.

Methods  Heidenhain pouches were fashioned from the greater curvature of the stomach in six mongrel

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