0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Effect of Variations in Antrum Acidity on Gastrin Release

CARLOS de la ROSA, MD; CARLOS A. MANZANO, MD; EDWARD R. WOODWARD, MD; LESTER R. DRAGSTEDT, MD, PhD
Arch Surg. 1966;93(2):286-290. doi:10.1001/archsurg.1966.01330020078011.
Text Size: A A A
Published online

IN 1954 Woodward et al1 reported that irrigation of isolated vagus-innervated antrum pouches in dogs with liver solutions produced a vigorous secretion of gastric juice from a Heidenhain pouch when the perfusate was neutral or faintly alkaline in reaction but little or no secretion where the perfusate was acidified. In later experiments with the same types of preparation, Woodward and his associates2 found that the secretory response to distention of the isolated antrum was also regularly blocked when the antrum was perfused with N 10 HCl solutions. N 50 HCl with a pH of 1.7 was found to be ineffectual. Nitric and sulfuric acids were equally as effective as HCl indicating that the important factor was the hydrogen concentration. These early observations have been repeatedly confirmed and the later work has been very largely directed to the question: does acidification of the antrum cause the release of a

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();