THE USE of a plastic adhesive, methyl 2-cyanoacrylate (Eastman 910 Monomer) has been investigated in many laboratories. Studies have included its application to the gastrointestinal tract,1 blood vessels and heart,2-5 liver,6 and lung.7,8 In general, this material has been used successfully in each of these anatomic areas. Results have indicated that it is self-sterilizing, is accompanied by minimal foreign body reaction, and forms a strong seal when used for anastomoses of luminal structures. The present investigation was undertaken further to evaluate its use in cardiovascular surgery.
Methods and Materials
Mongrel dogs weighing 15 to 30 kg were anesthetized using sodium pentobarbital administered intravenously. Animals undergoing thoracic operations had endotracheal intubation and were attached to a mechanical respirator during surgery. Anticoagulants and antibiotics were not used postoperatively. Four groups of dogs were prepared.
—In ten animals the chest was entered through a lateral incision over