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Observation of Antacids by Intragastric Photography

Arch Surg. 1966;93(3):467-474. doi:10.1001/archsurg.1966.01330030097020.
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CURIOSITY concerning conflicting claims and the availability of a suitable investigating instrument led to this photographic study of gastric antacids. The observations here are photographic and not chemical, yet they constitute an attempt to add useful knowledge concerning the action of the tested drugs in a human stomach. The claims and questions are as follows. Do the antacids really coat an ulcer and the inflamed mucosa like a salve? Are liquid forms more efficient than tablet forms? What, if anything, is the significance of antifoaming agents? Do they work? Do antacids remain in the stomach for a short or a long period?

The investigating device used was the Japanese-invented gastrocamera which permits intragastric photography of a high degree of definition. The camera was developed in Japan during the 1950's1 but not introduced clinically in the United States until 1963 and 1964.2,3 It consists of a small camera actually


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