MANY types of acute pulmonary emboli occur and have attracted widespread clinical and experimental attention. Less work has been done relating to recurrent pulmonary embolism, an unfortunately common clinical experience. The following experiment was designed to discover the effect of a sublethal pulmonary embolus on subsequent embolization.
Adult mongrel dogs weighing between 11 and 20 kg were anesthetized with sodium pentobarbital and placed in the supine position. Olive oil, USP, in dosage of 1.5 cc/kg was used as the final embolic agent in all animals. This was injected intravenously at the rate of 3 cc/min. Systemic arterial and right ventricular pressures were measured using strain gauges and an electronic recorder. Plastic catheters for this purpose were inserted into the aorta and the right ventricle from the femoral vessels.Any animal living 48 hours or longer was counted as a survivor. Sections were taken from the lung, kidney, and in