0
ARTICLE |

The Effect of High Pressure Oxygen and Nitrogen Mustard on the Ehrlich Ascites Tumor

ALVIN COHEN, MD; NOAH WEG, BA; GARY L. FANNING, MD; JOSEPH V. COLLEA, MD; MICHAEL A. RUSSO, MD; LLOYD S. ROGERS, MD; JEROME J. DeCOSSE, MD
Arch Surg. 1966;93(4):638-642. doi:10.1001/archsurg.1966.01330040102019.
Text Size: A A A
Published online

IN 1953, Gray and co-workers1 demonstrated that Ehrlich ascites tumor cells showed increased sensitivity to x-ray irradiation when the cells were also exposed to high concentrations of oxygen. Subsequent laboratory studies2 and clinical trials3 have substantiated the evidence for potentiation of x-ray irradiation by high pressure oxygen (HPO, hyperbaric oxygen).

Because x-ray irradiation and the alkylating agents have clinical, cytological, and biochemical similarities in their effects,4,5 several investigators have tested the combined effect of high pressure oxygen and chemotherapy in the laboratory,4,6-8 and two groups have performed clinical trials.9,10 We are reporting a study of the individual and combined effects of nitrogen mustard and high pressure oxygen as suppressors of Ehrlich ascites tumor in mice. The parameters for response to treatment were survival and the total number of viable tumor cells. The latter was calculated as the product of the tumor cell count per

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();