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Hemodynamic Effects of Pulsatile and Nonpulsatile Flow

FABIO GIRON, MD; WILLIAM C. BIRTWELL, BS; HARRY S. SOROFF, MD; RALPH A. DETERLING JR., MD
Arch Surg. 1966;93(5):802-810. doi:10.1001/archsurg.1966.01330050106015.
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THE RENEWED interest in the physiologic effects of pulsatile and nonpulsatile flow has been, in large measure, stimulated by the desire to support the circulation for prolonged periods with extracorporeal devices. The excellent studies of Mandelbaum and associates,1,2 Wesolowski,3 Ogata and associates,4 Nakayama et al,5 and Dalton et al6 have all used extracorporeal devices to provide either pulsatile or nonpulsatile flow. While these studies have been illuminating and have generally pointed to a significant increase in pressure and resistance in response to a nonpulsatile flow, the use of extracorporeal devices as the source of the flow has made the application of these findings to the intact organism open to serious question.

This group has adopted a different approach. We have introduced an experimental model for studying the chronic effects of depulsation in which the aortic flow is exteriorized through a subcutaneous graft anastomosed in-series to

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